Substituted alkanohydroxamic acids and method of reducing...

Details Substituted alkanohydroxamic acids and method of reducing... Substituted alkanohydroxamic acids and method of reducing...

C - Chemistry, Metallurgy

07

D

C07D 209/48 (2006.01) A61K 31/4035 (2006.01) C07D 209/46 (2006.01) C07D 209/66 (2006.01)

Patent

CA 2295295

Imido and amido substituted alkanohydroxamic acids reduce the levels of TNF.alpha. and inhibit phosphodiesterase in a mammal. A typical embodiment is 3-(3-cyclopentyloxy-4-methoxyphenyl)-N-hydroxy-3-phthalimidopropionamide.

L'invention concerne des acides alcanohydroxamiques imido- et amido-substitués qui réduisent le niveau de TNF-.alpha. et inhibent la phosphodiestérase chez les mammifères. Une mode de réalisation type est le 3-(3-cyclopentyloxy-4-méthoxyphényl)-N-hydroxy-3-phthalimidopropionamide.

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