1,2,4-oxadiazole derivatives having monoamine oxidase b...

Details 1,2,4-oxadiazole derivatives having monoamine oxidase b... 1,2,4-oxadiazole derivatives having monoamine oxidase b...

C - Chemistry, Metallurgy

07

D

C07D 413/12 (2006.01) A61K 31/42 (2006.01) A61K 31/44 (2006.01) A61K 31/495 (2006.01) A61K 31/535 (2006.01) C07D 271/06 (2006.01) C07D 521/00 (2006.01)

Patent

CA 2060569

Abstract of the Disclosure A 1,2,4-oxadiazole derivative is represented by the following general formula (I): Image (I) wherein R1 represents a lower alkyl or cycloalkyl group, a lower alkyl group substituted with a halogen atom, a lower alkylamino group or a phenyl group; R2 represents a hydrogen atom, a lower dialkylamino group, a cyclic alkylamino group, a cyclic amino group having an oxygen or nitrogen atom in the ring, a phenyl group which may be substituted with a halogen atom, a pyridyl group, an imidazolyl group, an alkylimidazolyl group, a benzimidazolyl group or a 2-oxopyrrodinyl group; and n is 1, 2 or 3. The derivative. has excellent monoamine oxidase-inhibitory activity and is effective as a medicine for treating Parkinson's disease.

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