Compositions of lipoxygenase inhibitors

Details Compositions of lipoxygenase inhibitors Compositions of lipoxygenase inhibitors

A - Human Necessities

61

K

A61K 9/14 (2006.01) A61K 9/10 (2006.01) A61K 9/19 (2006.01) A61K 31/38 (2006.01) A61P 1/00 (2006.01) A61P 9/10 (2006.01) A61P 11/06 (2006.01) A61P 17/06 (2006.01) A61P 17/10 (2006.01) A61P 29/00 (2006.01) A61P 35/00 (2006.01) A61P 37/08 (2006.01)

Patent

CA 2628630

Pharmaceutical compositions comprising particles of lipoxygenase inhibitor compounds having an effective average size of from about 10 nm to about 50 microns are provided. More particularly, pharmaceutical compositions of particle of a 5 -lipoxygenase inhibitor compound having an effective average size of from about 50 nm to about 5 microns are provided. The pharmaceutical compositions are in the form of aqueous suspensions with the particle of the 5- lipoxygenase-inhibitor compound present in concentrations of from about 5 to about 200 mg/ml. In addition, methods for making such pharmaceutical compositions are provided. In particular, microprecipitation and direct homogenization in the presence of at least one surfactant are disclosed for making the pharmaceutical compositions.

L'invention concerne des compositions pharmaceutiques comprenant des particules de composés inhibiteurs de lipoxygénase présentant une taille moyenne effective comprise entre environ 10 nm et environ 50 micromètres. Plus particulièrement, l'invention concerne des compositions pharmaceutiques renfermant des particules d'un composé inhibiteur de 5-lipoxygénase présentant une taille moyenne effective comprise entre environ 50 nm et environ 5 micromètres. Ces compositions pharmaceutiques se présentent sous la forme de suspensions aqueuses, les particules du composé inhibiteur de 5-lipoxygénase étant présentes en concentrations comprises entre environ 5 et environ 200 mg/ml. L'invention se rapporte en outre à des procédés de fabrication de ces compositions pharmaceutiques. Plus particulièrement, elle porte sur une microprécipitation et une homogénéisation directe en présence d'au moins un tensioactif pour la fabrication de ces compositions pharmaceutiques.

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