Method for designing dna-binding proteins of the zinc-finger...

Details Method for designing dna-binding proteins of the zinc-finger... Method for designing dna-binding proteins of the zinc-finger...

C - Chemistry, Metallurgy

07

K

C07K 1/00 (2006.01) C07K 14/00 (2006.01) C07K 14/47 (2006.01) G06F 17/50 (2006.01)

Patent

CA 2321088

The invention is directed to the design of DNA-binding proteins (DBP's) with capabilities of binding to any predetermined target double-stranded DNA sequence. Disclosed are the rules for design of the proteins; an algorithm for screening for the optimal DBP's; a computer system employing the rules and the algorithm; general formulae encompassing the proteins; and methods of use of the proteins.

L'invention concerne la conception de protéines liant l'ADN capables de se lier à n'importe quelle séquence d'ADN cible à double brin. L'invention concerne les règles de conception pour ces protéines, un algorithme permettant de sélectionner les protéines liant l'ADN optimales, un système informatique utilisant ces règles et ces algorithmes, des formules générales définissant ces protéines et des procédés d'utilisation de ces protéines.

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