2-anilino-4-(heterocyclic)amino-pyrimidines

Details 2-anilino-4-(heterocyclic)amino-pyrimidines 2-anilino-4-(heterocyclic)amino-pyrimidines

C - Chemistry, Metallurgy

07

D

C07D 239/48 (2006.01) A61K 31/505 (2006.01) A61K 31/506 (2006.01) A61P 9/00 (2006.01) C07D 401/12 (2006.01) C07D 403/12 (2006.01) C07D 413/12 (2006.01) C07D 417/12 (2006.01)

Patent

CA 2653777

The present invention relates to 2-arylamino-4-(heterocyclic)aminopyrimidines inhibitors which are inhibitors and therefore inhibit Protein Kinase C-alpha (PKC-a). The PKC-a inhibitors of the present invention are important for improving myocardial intracellular calcium cycling, resulting in improved myocardial contraction and relaxation performance and thereby slowing the progression of heart failure. The present invention further relates to compositions comprising said 2-arylamino-4-(heterocyclic)amino-pyrimidines and to methods for controlling, abating, or otherwise slowing the progression of heart failure.

La présente invention concerne des 2-arylamino-4-(hétérocyclique)amino-pyrimidines qui sont des inhibiteurs et inhibent par conséquent la protéine kinase C-alpha (PKC-a). Les inhibiteurs de la PKC-a de la présente invention sont importants en ce qu'ils améliorent le cycle du calcium intracellulaire myocardique, permettant ainsi une meilleure performance de contraction et de relaxation myocardique et ralentissant par conséquent l'évolution d'une défaillance cardiaque. La présente invention concerne en outre des compositions contenant lesdites 2-arylamino-4-(hétérocyclique)amino-pyrimidines et des procédés destinés à la régulation, la réduction ou sinon le ralentissement de l'évolution d'une défaillance cardiaque.

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