Method for delivering a pharmaceutical composition to...

Details Method for delivering a pharmaceutical composition to... Method for delivering a pharmaceutical composition to...

A - Human Necessities

61

K

A61K 9/20 (2006.01) A61K 31/192 (2006.01) A61K 31/4439 (2006.01) A61P 1/04 (2006.01) A61P 19/02 (2006.01)

Patent

CA 2736547

The present disclosure is directed to the use of naproxen, or pharmaceutically acceptable salt thereof, and esomeprazole, or pharmaceutically acceptable salt thereof in the manufacture of a pharmaceutical composition in unit dose form, wherein said esomeprazole, or pharmaceutically acceptable salt thereof, is released from said unit dose form at a specified pH, wherein one unit dose form is for administration as an AM dose and a second unit dose form is for administration about 10 hours later as a PM dose to target a specified pharmacokinetic profile.

La présente invention porte sur l'utilisation de naproxène ou d'un sel pharmaceutiquement acceptable de celui-ci et d'ésoméprazole ou d'un sel pharmaceutiquement acceptable de celui-ci dans la fabrication d'une composition pharmaceutique sous forme posologique unitaire, ledit ésoméprazole ou ledit sel pharmaceutiquement acceptable de celui-ci étant libéré de ladite forme posologique unitaire à un pH spécifié de 5. Une forme posologique unitaire est destinée à une administration sous forme de dose du matin et une seconde forme posologique unitaire est destinée à une administration environ 10 heures plus tard, sous forme de dose d'après-midi, afin d'obtenir un profil pharmacocinétique spécifié.

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