A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 9/51 (2006.01)
Patent
CA 2714429
The invention provides a process for the production of nanoparticle carriers for drug delivery, said nanoparticles being produced by preparing a double emulsion of water-oil-water including one or more polymer which forms the basis of the nanoparticle carrier, blending the drug to be delivered into one of the emulsion phases, doping either the oil-phase or the outer-water phase with a carbohydrate, and spray drying the emulsion to form nanoparticles of a narrow particle size distribution of 100 nm to 1000 nm, which nanoparticles are substantially spherical.
Linvention concerne un procédé de fabrication de vecteurs de nanoparticules pour ladministration de médicaments, lesdites nanoparticules étant fabriquées en préparant une émulsion double deau-huile-eau qui comprend un ou plusieurs polymères qui forment la base du vecteur de nanoparticules, en mélangeant le médicament à administrer dans une des phases de lémulsion, en dopant soit la phase huileuse ou la phase aqueuse externe avec un hydrate de carbone, et en séchant par atomisation lémulsion pour former des nanoparticules dune répartition granulométrique étroite de 100 nm à 1000 nm, les nanoparticules étant essentiellement sphériques.
Csir
Gowling Lafleur Henderson Llp
LandOfFree
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