Antibodies that specifically bind to chemokine beta-4

Details Antibodies that specifically bind to chemokine beta-4 Antibodies that specifically bind to chemokine beta-4

C - Chemistry, Metallurgy

12

N

C12N 15/13 (2006.01) A61K 39/395 (2006.01) C07K 16/24 (2006.01) C07K 19/00 (2006.01) G01N 33/53 (2006.01)

Patent

CA 2484121

The present invention relates to antibodies and related molecules that specifically bind to CK-B4. Such antibodies have uses, for example, in the prevention and treatment of cancer as well as immune system diseases and disorders including cancers, as well as immune system diseases and disorders including autoimmune diseases, inflammatory disorders, immunodeficiencies, infections, HIV, arthritis, allergy, psoriasis, dermatitis, and inflammatory bowel disease. The invention also relates to nucleic acid molecules encoding anti-CK-B4 antibodies, vectors and host cells containing these nucleic acids, and methods for producing the same. The present invention relates to methods and compositions for preventing, detecting, diagnosing, treating or ameliorating a disease or disorder, especially cancers, as well as immune system diseases and disorders including autoimmune disease, inflammatory disorders, immunodeficiencies, infections, HIV, arthritis, allergy, psoriasis, dermatitis, and inflammatory bowel disease, comprising administering to an animal, preferably a human, an effective amount of one or more antibodies or fragments or variants thereof, or related molecules, that specifically bind to CK-B4.

L'invention concerne des anticorps et des molécules apparentées se liant spécifiquement à la CK-B4. Ces anticorps sont utilisables, par exemple, pour la prévention et le traitement du cancer ainsi que des maladies et des troubles du système immunitaire englobant le cancer, et aussi des maladies et des troubles du système immunitaire englobant la maladie auto-immune, les troubles inflammatoires, les immunodéficiences, les infections, le VIH, l'arthrite, l'allergie, le psoriasis, la dermatite, et la maladie intestinale inflammatoire. L'invention concerne également des molécules d'acides nucléiques codant les anticorps anti-CK-B4, des vecteurs et des cellules hôtes renfermant les acides nucléiques en question, et des procédés d'élaboration correspondants. L'invention concerne en outre des procédés et des compositions pour la prévention, la détection, le diagnostic, le traitement ou l'atténuation d'une maladie ou d'un trouble, en particulier le cancer, ainsi que des maladies et des troubles du système immunitaire englobant la maladie auto-immune, les troubles inflammatoires, les immunodéficiences, les infections, le VIH, l'arthrite, l'allergie, le psoriasis, la dermatite, et la maladie intestinale inflammatoire, ces procédés consistant à administrer à un animal, de préférence à un être humain, une quantité efficace d'un ou plusieurs anticorps ou bien de fragments ou de variants correspondants, ou encore de molécules apparentées, qui se lient spécifiquement à la CK-B4.

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