A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 38/57 (2006.01)
Patent
CA 2194443
A method is disclosed for attenuating stenosis after balloon angioplasty. The method comprises administering parenterally to a subject following balloon angioplasty an effective amount of tissue factor pathway inhibitor (TFPI) sufficient to reduce the extent of restenosis. An exemplary amount of the TFPI is from about 0.5 mg/kg to about 6 mg/kg during a prolonged administration of about three (3) hours to 24 hours.
L'invention concerne un procédé permettant d'atténuer les sténoses artérielles suite à une intervention d'angioplastie percutanée tansluminale. Selon l'invention, le procédé consiste à administrer par voie parentérale, après un traitement par angioplastie percutanée transluminale, une quantité efficace d'un inhibiteur des voies de la thromboplastine tissulaire suffisante pour réduire l'ampleur de la resténose, par exemple, variant entre environ 0,5 mg/kg et environ 6 mg/kg pendant une administration prolongée comprise entre environ 3 heures et 24 heures.
Osler Hoskin & Harcourt Llp
Washington University
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