C - Chemistry – Metallurgy – 12 – Q
Patent
C - Chemistry, Metallurgy
12
Q
C12Q 1/68 (2006.01) A01K 67/02 (2006.01) A01K 67/027 (2006.01) C12Q 1/00 (2006.01)
Patent
CA 2337406
A method for breeding mutagenized mice that permits detection of genetic loci that can modify a known index phenotype involves crossing a mutagenized founder strain and a second strain of mice carrying an allele at a locus that confers the index phenotype. In the test generation, clusters of individuals are observed to deviate from the typical phenotype. The genetic material and molecules encoded thereby can be obtained using available methods. Improved and compact methods are also disclosed.
L'invention concerne un procédé permettant d'élever des souris mutagénisées afin de détecter des loci génétiques pouvant modifier un phénotype index connu, ce procédé consistant notamment à croiser une souche fondatrice mutagénisée avec une seconde souche de souris porteuse d'un allèle sur un locus conférant ledit phénotype index. Dans la génération testée, on observe des groupes d'individus qui s'écartent du phénotype habituel. On peut donc obtenir le matériel génétique et les molécules ainsi codées au moyen des procédés disponibles. Cette invention concerne également des procédés compacts améliorés.
Dove William F.
Shedlovsky Alexandra
Gowling Lafleur Henderson Llp
Wisconsin Alumni Research Foundation
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