Tissue engineered cartilage for drug discovery

Details Tissue engineered cartilage for drug discovery Tissue engineered cartilage for drug discovery

C - Chemistry, Metallurgy

12

Q

C12Q 1/00 (2006.01) C12Q 1/25 (2006.01)

Patent

CA 2473903

A culture system and method for determining the effect of a test agent on the development, homeostasis or degradation of engineered cartilage tissue. The engineered cartilage tissue is obtained by isolating chondrogenic cells and culturing them to obtain chondrocytes in a cell-associated matrix. The chondrocytes and cell associated matrix are then cultured on a semipermeable membrane to provide the engineered cartilage tissue. The engineered tissue, or one of its precursors, can be contacted with the test agent to determine what effect, if any, the test agent has on engineered cartilage.

L'invention concerne un système et un procédé de culture pour déterminer l'effet d'un agent test sur le développement, l'homéostase ou la dégradation d'un substitut cartilagineux. Ce substitut cartilagineux est obtenu par l'isolation et la culture de cellules chondrogéniques pour obtenir des chondrocytes dans une matrice associée aux cellules. Puis les chondrocytes et la matrice associée aux cellules sont cultivés sur une membrane semi-perméable pour créer le substitut cartilagineux. Ce substitut ou un de ses précurseurs peut alors être mis en contact avec l'agent test pour déterminer si cet agent test a un effet quelconque sur le substitut cartilagineux et, si oui, lequel.

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