A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 31/4535 (2006.01) A61K 9/14 (2006.01) A61P 19/10 (2006.01) A61P 35/00 (2006.01)
Patent
CA 2589824
The present invention is directed to benzothiophene compositions, preferably nanoparticulate raloxifene hydrochloride compositions, having improved pharmacokinetic profiles, improved bioavailability, dissolution rates and efficacy. In one embodiment, the raloxifene hydrochloride nanoparticulate composition have an effective average particle size of less than about 2000 nm.
La présente invention concerne des compositions de benzothiophène, de préférence des compositions nanoparticulaires de chlorhydrate de raloxifène présentant des profils pharmacocinétiques, une biodisponibilité, des vitesses de dissolution et une efficacité améliorés. Dans un mode de réalisation, la composition nanoparticulaire de chlorhydrate de raloxifène présente une dimension granulométrique moyenne effective inférieure à environ 2000 nm.
Jenkins Scott
Liversidge Gary
Elan Pharma International Ltd.
Smart & Biggar
LandOfFree
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