Mutants of human interleukin-3

Details Mutants of human interleukin-3 Mutants of human interleukin-3

C - Chemistry, Metallurgy

12

N

C12N 15/24 (2006.01) A61K 38/00 (2006.01) A61K 38/18 (2006.01) A61K 38/19 (2006.01) A61K 38/20 (2006.01) C07K 14/53 (2006.01) C07K 14/54 (2006.01) C07K 16/24 (2006.01) C12N 1/21 (2006.01) C12N 5/10 (2006.01) C12N 15/09 (2006.01) C12N 15/27 (2006.01) C12P 21/02 (2006.01) C12P 21/08 (2006.01) A61K 39/395 (2006.01) A61P 3/02 (2006.01) A61P 7/00 (2006.01) A61P 35/00 (2006.01) A61P 37/00 (2006.01)

Patent

CA 2023246

Mutants of hIL-3 are provided having deletions covering virtually the complete coding region of hIL-3, while retaining their biological activity. Preferred mutants are those having one or more deletions at the N-terminus (amino acids 1-14) and/or the C-terminus (amino acids 116-133, 120- 130 and/or 130-133). Another preferred group of mutants are substitution mutants. Some of these mutants have an antagonistic effect. Specific examples are Cys -> Ala mutants (Cys16 -> Ala16, Cys16Cys84 -> Ala16Ala84). Other mutants having an antagonistic effect are Glu50 -> Lys50 and Lys79 -> Glu79. Finally antibodies are provided aimed at specific epitopes localized between amino acids 29 and 54.

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