Lipid carrier compositions and methods for improved drug...

Details Lipid carrier compositions and methods for improved drug... Lipid carrier compositions and methods for improved drug...

A - Human Necessities

61

K

A61K 9/127 (2006.01) A61K 9/133 (2006.01)

Patent

CA 2467060

Liposomal compositions which have enhanced retention properties for biological agents are characterized by an intrasomal osmolarity of 500 mOSM/kg or less and by containing substantially no cholesterol. The liposomes comprise vesicle forming lipids along with aggregation preventing components, and typically have transition temperatures of 38 ~C or higher.

Cette invention concerne des compositions liposomiques présentant des propriétés de rétention médicamenteuse améliorées pour des agents biologiques, qui se caractérisent par une osmolarité de 500 mOSM/kg ou moins et qui sont sensiblement exemptes de cholestérol. Les liposomes, qui comprennent des lipides formant des vésicules et des inhibiteurs d'agrégation, ont généralement des températures de transition 38 ·C ou plus.

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