Piperidine derivatives useful as ccr5 antagonists

Details Piperidine derivatives useful as ccr5 antagonists Piperidine derivatives useful as ccr5 antagonists

C - Chemistry, Metallurgy

07

D

C07D 401/04 (2006.01) A61K 31/435 (2006.01) A61P 31/18 (2006.01) C07D 401/14 (2006.01)

Patent

CA 2457861

The present invention provides a compound of the formula (I) or a pharmaceutically acceptable salt or solvate thereof, wherein R1, R2, R3, R9, R10, A and B are as defined in the specification. The present invention also provides pharmaceutical compositions containing the compound of this invention, and methods of treatment using the compound of this invention. The invention also relates to the use of a combination of a compound of this invention and one or more antiviral or other agents useful in the treatment of Human Immunodeficiency Virus (HIV). The invention further relates to the use of a compound of this invention, alone or in combination with another agent, in the treatment of solid organ transplant rejection, graft v. host disease, arthritis, rheumatoid arthritis, inflammatory bowel disease, atopic dermatitis, psoriasis, asthma, allergies or multiple sclerosis.

La présente invention concerne un composé représenté par la formule (I) ou un sel ou un solvant pharmaceutiquement acceptable de ce dernier. Dans cette formule, R?1¿, R?2¿, R?3¿, R?9¿, R?10¿, A et B sont tels que définis dans la description. Cette invention concerne également des compositions pharmaceutiques contenant le composé de cette invention, ainsi que des méthodes de traitement faisant intervenir ce composé. Cette invention traite également de l'utilisation d'une combinaison renfermant un composé de cette invention et un ou plusieurs agents antiviraux ou autres pour le traitement du virus de l'immunodéficience humaine (VIH). Elle concerne en outre l'utilisation d'un composé de cette invention, seul ou associé à un autre agent, pour traiter le rejet de transplantation d'organes pleins, la réaction de greffe contre hôte, l'arthrite, la polyarthrite rhumatoïde, la maladie intestinale inflammatoire, la dermatite atopique, l'asthme, les allergies ou la sclérose en plaques.

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