Monitoring and diagnosis of gastric emptying and gastroparesis

Details Monitoring and diagnosis of gastric emptying and gastroparesis Monitoring and diagnosis of gastric emptying and gastroparesis

A - Human Necessities

61

K

A61K 49/00 (2006.01)

Patent

CA 2498507

The invention relates to methods and compositions for measuring the rate of gastric emptying in animals, including humans. The methods of the invention measure the rate of stomach emptying by administration of a marker agent in a delayed-release formulation or food vehicle and blood or serum levels of the market agent are monitored over time. The blood or serum levels of a marker agent reflect the gastric emptying rate. Incorporating such agents in foods also delays the absorption of such agents and serves as a measure of digestion and gastric emptying. These methods may be used to screen for drugs, herbal substances and other compounds that modulate gastric emptying, such as by increasing prokinetic activity of the gastrointestinal tract.

L'invention concerne des procédés et des compositions de mesure de la vitesse du vidage gastrique chez les animaux, notamment les humains. Ces procédés permettent de mesurer la vitesse du vidage gastrique par administration d'un agent marqueur dans une formulation à libération retardée ou un véhicule alimentaire et des niveaux sanguins ou sériques de l'agent marqueur sont contrôlés dans le temps. Les niveaux sanguins ou sériques d'un agent marqueur reflètent la vitesse de visage gastrique. Le fait d'incorporer ces agents dans des aliments permet aussi de retarder l'absorption de ces agents et de servir de mesure de la digestion et du vidage gastrique. Ces procédés peuvent être utilisés afin de cribler des médicaments, des substances médicinales et autres composés qui modulent le visage gastrique, telle l'augmentation de l'activité procinétique du tractus gastro-intestinal.

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