A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 31/216 (2006.01) C07C 229/28 (2006.01)
Patent
CA 2576279
The invention describes novel nitrosated and/or nitrosylated compounds or pharmaceutically acceptable salts thereof, and novel compositions comprising at least one nitrosated and/or nitrosylated compound, and, optionally, at least one nitric oxide donor and/or at least one therapeutic agent. The invention also provides novel compositions and kits comprising at least one compound of the invention, that is optionally nitrosated and/or nitrosylated, and, optionally, at least one nitric oxide donor compound and/or at least one therapeutic agent. The invention also provides methods for treating ophthalmic disorders. The nitrosated and/or nitrosylated compounds are preferably nitrosated and/or nitrosylated (3-adrenergic antagonists and nitrosated and/or nitrosylated angiotensin-converting enzyme (ACE) inhibitors.
L'invention concerne de nouveaux composés nitrosés et/ou nitrosylés ou des sels acceptables sur le plan pharmaceutique de ceux-ci, ainsi que des nouvelles compositions contenant au moins un composé nitrosé et/ou nitrosylé, et, éventuellement, au moins au donneur d'acide nitrique et/ou au moins un agent thérapeutique. L'invention concerne également de nouvelles compositions et des nécessaires contenant au moins un composé de l'invention, qui est éventuellement nitrosé et/ou nitrosylé, et, éventuellement, au moins un composé donneur d'oxyde nitrique et/ou au moins un agent thérapeutique. L'invention concerne enfin des procédés destinés au traitement de troubles ophtalmiques. Les composés nitrosés et/ou nitrosylés sont de préférence des agonistes .beta.-adrénergiques nitrosés et/ou nitrosylés et des inhibiteurs de l'enzyme convertissant l'angiotensine (ACE) nitrosés et/ou nitrosylés.
Garvey David S.
Letts L. Gordon
Bennett Jones Llp
Nicox S.a.
Nitromed Inc.
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