Phenyl derivatives comprising an acetylene group

Details Phenyl derivatives comprising an acetylene group Phenyl derivatives comprising an acetylene group

C - Chemistry, Metallurgy

07

C

C07C 59/68 (2006.01) A61K 31/192 (2006.01) A61P 3/10 (2006.01) C07C 59/70 (2006.01) C07C 69/736 (2006.01) C07C 235/34 (2006.01) C07C 323/20 (2006.01) C07D 213/30 (2006.01) C07D 239/26 (2006.01)

Patent

CA 2571722

This invention is concerned with compounds of the formula (I) wherein one of R5, R6 and R7 is formula (II) and X1, X2, R1 to R12, m, n and o are as defined in the description, and pharmaceutically acceptable salts and/or esters thereof. The invention further relates to pharmaceutical compositions containing such compounds, to a process for their preparation and to their use for the treatment and/or prevention of diseases which are modulated by PPAR.delta. and/or PPAR.alpha. agonists.

La présente invention concerne décomposée représentée par la formule (I). Dans cette formule R5, R6 et R7 sont représentés par la formule (II) et X1, X2, R1 à R12, m, n et o sont tels que défini fin s dans les descriptions. Cette invention concerne aussi des sels et/ou des esters de ces composés répondant aux normes pharmaceutiques. C'est invention concerne aussi des compositions pharmaceutiques contenant ces composés, un processus de préparation de ses compositions et l'utilisation de celles-ci pour le traitement et/ou la prévention de maladie qui sont modulées par des agonistes PPARd et/ou PPARa.

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