Squaric acid derivatives as inhibitors of histone deacetylase

Details Squaric acid derivatives as inhibitors of histone deacetylase Squaric acid derivatives as inhibitors of histone deacetylase

C - Chemistry, Metallurgy

07

D

C07D 239/42 (2006.01) A61K 31/505 (2006.01) A61K 31/506 (2006.01) A61P 35/00 (2006.01) C07D 401/12 (2006.01) C07D 403/12 (2006.01)

Patent

CA 2623360

This invention comprises the novel compounds of Formula (I) wherein R1, R2 and X have defined meanings, having histone deacetylase inhibiting enzymatic activity; their preparation, compositions containing them and their use as a medicine.

La présente invention a pour objet les nouveaux composés de Formule (I) où R1, R2 et X sont tels que définis dans l'invention, lesdits composés présentant une activité inhibitrice de l'enzyme histone désacétylase. La présente invention a également pour objet la synthèse desdits composés, les préparations les contenant et leur emploi en tant que médicaments.

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