Benzyloxy derivatives as maob inhibitors

Details Benzyloxy derivatives as maob inhibitors Benzyloxy derivatives as maob inhibitors

C - Chemistry, Metallurgy

07

D

C07D 207/27 (2006.01) A61K 31/4015 (2006.01) A61K 31/4025 (2006.01) A61P 25/00 (2006.01) C07D 207/277 (2006.01) C07D 403/04 (2006.01) C07D 413/04 (2006.01) C07D 417/04 (2006.01)

Patent

CA 2575018

The present invention relates to compounds of the general formula (I); wherein Rl is halogen; R2 is -C(O)NH2,-C(NH2)=N-OH, -C(O)CH2Br, -C(O)N(CH3)OCH3 or- C(O)-lower alkyl, or is a 5-membered heteroaryl group, containing 2 or 3 heteroatoms, selected from the group consisting of N, O or S, optionally substituted by R3, wherein R3 is lower alkyl, -NR'R" or -C(O)R; R is NR'R", lower alkyl, or lower alkoxy; R'/R" are independently hydrogen or lower alkyl; as well as their pharmaceutically acceptable salts for the treatment of diseases, which are mediated by monoamine oxidase B inhibitors, for example Alzheimer's disease and senile dementia.

La présente invention concerne des composés de formule générale (I) dans laquelle R1 représente halogène; R2 représente -C(O)NH2,-C(NH2)=N-OH, -C(O)CH2Br, -C(O)N(CH3)OCH3, -C(O)-alkyle inférieur ou un groupe hétéroaryle à 5 éléments, contenant 2 ou 3 hétéroatomes choisis dans le groupe formé par N, O et S, éventuellement substitué par R3, R3 étant alkyle inférieur, -NR'R'' ou -C(O)R; R représente NR'R", alkyle inférieur ou alkoxy inférieur; R'/R'' sont indépendamment hydrogène ou alkyle inférieur, ainsi que des sels de ceux-ci, acceptables d'un point de vue pharmaceutique, qui sont utilisés pour traiter des maladies dont la médiation est assurée par des inhibiteurs de la monoamine oxydase B, par exemple la maladie d'Alzheimer et la démence sénile.

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