C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 403/02 (2006.01) A61K 31/4439 (2006.01) A61K 31/444 (2006.01) A61K 31/4523 (2006.01) A61K 31/454 (2006.01) A61K 31/4545 (2006.01) A61K 31/496 (2006.01) C07D 233/70 (2006.01) C07D 401/02 (2006.01) C07D 401/06 (2006.01) C07D 401/14 (2006.01) C07D 403/06 (2006.01) C07D 403/14 (2006.01) C07D 405/14 (2006.01) C07D 491/10 (2006.01)
Patent
CA 2355202
This invention is directed to imidazolones which are selective antagonists for human .alpha.1a receptors. This invention is also related to uses of these compounds for lowering intraocular pressure, inhibiting cholesterol synthesis, relaxing lower urinary tract tissue, the treatment of benign prostatic hyperplasia, impotency, cardiac arrhythmia, sympathetic mediated pain, migraine, and for the treatment of any disease where the antagonism of the .alpha.1a receptor may be useful. The invention further provides a pharmaceutical composition comprising a therapeutically effective amount of the above-defined compounds and a pharmaceutically acceptable carrier.
L'invention concerne des imidazolones qui sont des antagonistes sélectifs des récepteurs .alpha.¿1a? humains. L'invention concerne également l'utilisation de ces composés pour abaisser la pression intraoculaire, inhiber la synthèse de cholestérol, détendre les tissus des voies urinaires inférieures, traiter l'hyperplasie prostatique bénigne, l'impuissance, l'arythmie, les douleurs d'origine sympathique, la migraine et toute autre maladie où seraient utiles les antagonistes des récepteurs .alpha.¿1a? humains. L'invention concerne en outre une composition pharmaceutique comprenant une quantité thérapeutiquement efficace des composés définis plus haut et un excipient pharmaceutiquement acceptable.
Gluchowski Charles
Murali Dhar T. G.
Wong Wai C.
Ogilvy Renault Llp/s.e.n.c.r.l.,s.r.l.
Synaptic Pharmaceutical Corporation
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