Pyrazolotriazines as kinase inhibitors

Details Pyrazolotriazines as kinase inhibitors Pyrazolotriazines as kinase inhibitors

C - Chemistry, Metallurgy

07

D

C07D 487/04 (2006.01) A61K 31/53 (2006.01) A61P 35/00 (2006.01)

Patent

CA 2557184

In its many embodiments, the present invention provides a novel class of pyrazolo[1,5-a]triazine compounds as inhibitors of kinases such as, for example, cyclin dependent kinases, methods of preparing such compounds, pharmaceutical compositions containing one or more such compounds, methods of preparing pharmaceutical formulations comprising one or more such compounds, and methods of treatment, prevention, inhibition, or amelioration of one or more diseases associated with the kinases using such compounds or pharmaceutical compositions.

Dans certains modes de réalisation, la présente invention concerne une nouvelle classe de composés de pyrazolo[1,5-a]triazine en tant qu'inhibiteurs de kinases, telles que, par exemple, des kinases dépendantes de la cycline, des méthodes de préparation de tels composés, des compositions pharmaceutiques renfermant au moins un de ces composés, des méthodes de conception de préparations pharmaceutiques contenant au moins un de ces composés et des méthodes de traitement, de prévention, d'inhibition ou d'amélioration d'au moins une maladie liée aux kinases au moyen de ces composés ou de ces compositions pharmaceutiques.

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