Process for manufacturing sutures from copolymers of...

A - Human Necessities – 61 – L

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A61L 17/00 (2006.01) A61L 17/12 (2006.01) D01F 6/84 (2006.01) A61B 17/00 (2006.01) A61B 17/06 (2006.01)

Patent

CA 2215775

We have discovered a process for producing a suture from copolymers of glycolide and .epsilon.-caprolactone comprising the steps of (a) extruding a melted copolymer of a glycolide and .epsilon.-caprolactone resin through an orifice and rapidly quenching the melted copolymer resin to produce a filament; (b) drawing the filament in the range of from about 4X to about 7.5X to produce a singly drawn filament; (c) drawing the singly drawn filament in the range of form about 1X to about 3X in a first heated zone being maintained at a temperature in the range of from about 150°F to about 450°F, to form a doubly drawn filament (d) shrinking the doubly drawn filament in the range of from about 0.75 percent to about 0.98 percent in a second heated zone being maintained at a temperature in the range of from about 100°F to about 400°F to form a relaxed filament then rack annealing the relaxed filament to form a glycolide/.epsilon.-caprolactone suture.

Nous avons découvert un procédé pour l'obtention d'un fil de suture à partir de copolymères de glycolide et d'epsilon-caprolactone, comprenant les étapes suivantes : a) extrusion d'un copolymère fondu, à base d'une résine d'epsilon-caprolactone et de glycolide, à travers un orifice, puis trempe rapide de la résine de copolymère fondue pour l'obtention d'un filament; b) étirage du filament de 4X à 7,5X environ, donnant un monofilament étiré; c) étirage du monofilament de 1X à 3X environ, dans une première zone chauffée, maintenue à une température de 150 à 450 degrés F environ, pour former un filament étiré double; d) rétrécissement du filament double de 0,75 à 0,98 % environ dans une seconde zone chauffée, maintenue à une température de 100 à 400 degrés F environ pour former un filament souple, puis recuit sur support de ce filament pour l'obtention d'un fil de suture de glycolide/epsilon-caprolactone.

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