Inhibitors of akt activity

Details Inhibitors of akt activity Inhibitors of akt activity

C - Chemistry, Metallurgy

07

D

C07D 487/14 (2006.01) A61K 31/395 (2006.01) C07D 471/14 (2006.01)

Patent

CA 2610888

The instant invention provides for substituted naphthyridine compounds that inhibit Akt activity. In particular, the compounds disclosed selectively inhibit one or two of the Akt isoforms. The invention also provides for compositions comprising such inhibitory compounds and methods of inhibiting Akt activity by administering the compound to a patient in need of treatment of cancer.

L'invention concerne des composés de naphthyridine substitués qui inhibent l'activité Akt. Notamment, les composés de cette invention permettent d'inhiber sélectivement au moins deux des isoformes Akt. Ladite invention a aussi pour objet des compositions renfermant de tels composés inhibiteurs et des méthodes d'inhibition de l'activité Akt par administration du composé à un patient nécessitant un traitement contre le cancer.

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