Use of nerve growth factor for the storage, culture or...

Details Use of nerve growth factor for the storage, culture or... Use of nerve growth factor for the storage, culture or...

C - Chemistry, Metallurgy

12

N

C12N 5/071 (2010.01) C12N 5/07 (2010.01) A01N 1/02 (2006.01) A61K 38/18 (2006.01)

Patent

CA 2287780

The nerve growth factor (NGF) is used for the storage of corneas in culture, for the production and the storage in vitro of single cell populations of the corneal morphological and functional unit (i.e., epithelium, stroma/keratocytes and endothelium) and of the conjunctival epithelium, and for the production and the storage of corneal and conjunctival tissues, in particular for transplantation purposes. The NGF is also proposed for use in the therapy and/or the prophylaxis of diseases of the corneal surface, wherein a lack of integrity of the corneal and conjunctival morphological and functional unit occurs, in particular for pathologies having a dystrophic or neurodystrophic basis, both congenital and acquired.

Le facteur de croissance du tissu nerveux (FCN) est utilisé pour la conservation de cornées en culture, pour la production et la conservation in vitro de populations unicellulaires provenant de l'ensemble morphologique et fonctionnel de la cornée (p. ex. épithélium, stroma/kératocytes et endothélium) et de l'épithélium conjonctif et pour la production et la conservation de tissus cornéens et conjonctifs, en particulier à des fins de transplantation. L'invention concerne également l'utilisation thérapeutique et/ou préventive du FCN pour des maladies de la surface cornéenne qui se traduisent par une atteinte de l'intégrité de l'ensemble morphologique et fonctionnel de la cornée et du tissu conjonctif, en particulier pour les pathologies d'origine dystrophique ou neurodystrophique, congénitales ou acquises.

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