Peripherally active anti-hyperalgesic opiates

Details Peripherally active anti-hyperalgesic opiates Peripherally active anti-hyperalgesic opiates

A - Human Necessities

61

K

A61K 31/00 (2006.01) A61K 31/17 (2006.01) A61K 31/439 (2006.01) A61K 31/445 (2006.01) A61K 31/451 (2006.01) A61K 31/454 (2006.01) A61K 31/4545 (2006.01) A61K 31/485 (2006.01) A61K 38/04 (2006.01) A61K 38/07 (2006.01) A61K 38/08 (2006.01) A61K 38/22 (2006.01) A61K 38/33 (2006.01) A61K 45/00 (2006.01)

Patent

CA 2229814

Compositions and methods using the compositions for treatment of peripheral hyperalgesia are provided. The compositions contain an anti-hyperalgesia effective amount of one or more compounds that directly or indirectly interact with peripheral opiate receptors, but that do not, upon topical or local administration, elicit substantial central nervous system effects. The anti-diarrheal compound 4-(p-chlorophenyl)- 4-hydroxy-N-N-dimethyl-.alpha.,.alpha.-diphenyl-1-piperidinebutyramide hydrochloride is preferred for use in the compositions and methods.

On décrit des compositions, et des procédés qui permettent de les utiliser, pour traiter l'hyperalgie périphérique. Ces compositions contiennent une quantité anti-hyperalgésique efficace d'un ou plusieurs composés qui interagissent, directement ou non, avec des récepteurs périphériques des opiacés mais n'entraînent pas d'effet marqué sur le système nerveux central en cas d'administration topique ou locale. Dans le cadre de l'utilisation de ces compositions et procédés, on retient de préférence un composé anti-diarrhéique, l'hydrochlorure de 4-(p-chlorophényl)-4-hydroxy-N-N-diméthyl- alpha , alpha -diphényl-1-pipéridinebutyramide.

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