Process for granulating particles

Details Process for granulating particles Process for granulating particles

A - Human Necessities

61

K

A61K 9/14 (2006.01) A61K 9/22 (2006.01) A61K 9/26 (2006.01) A61K 9/50 (2006.01) B05D 7/00 (2006.01)

Patent

CA 2586152

The invention encompasses a process for granulating particles that produces homogeneous, free flowing, attrition resistant, uniform sized granules using a Wurster unit operation (Fig. 1). When utilized with active pharmaceutical ingredients, such granules can be further processed into controlled released or taste- masked pharmaceutical formulations. Particularly, the process can be utilized to make an oral granule formulation of etoricoxib for treating pain and inflammation in patients that cannot swallow a tablet, such as young children and the elderly.

L'invention concerne un procédé de granulation de particules qui permet de produire des granules homogènes, à écoulement fluide, résistants à l'attrition et de taille uniforme. Utilisés avec des ingrédients pharmaceutiques actifs, ces granules peuvent encore être traités dans des formulations pharmaceutiques à libération régulée et au goût masqué. En particulier, le procédé peut servir à fabriquer une formulation en granules d'etoricoxib pour le traitement de la douleur et l'inflammation chez des patients dans l'incapacité d'avaler des comprimés, par exemple les jeunes enfants et les personnes âgées.

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