C - Chemistry – Metallurgy – 12 – Q
Patent
C - Chemistry, Metallurgy
12
Q
C12Q 1/68 (2006.01) C40B 30/00 (2006.01)
Patent
CA 2726356
The invention provides amplification-based methods for detecting hypermethylated or hypomethylated nucleic acid in heterogeneous biological samples, e.g. stool. A screening procedure based on the detection of hypermethylation, preferably at multiples genes, provides a means for detecting various diseases, e.g. colorectal cancer. By using chimeric primers that contain a 5' non-specific portion, the specificity and efficiency of the nucleic acid amplification is improved. Methods of the invention are especially useful in detection of rare events in a heterogeneous sample.
Esoterix Genetic Laboratories Llc
Genzyme Corporation
Ridout & Maybee Llp
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