C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 295/088 (2006.01) A61K 31/16 (2006.01) A61K 31/40 (2006.01) A61K 31/5375 (2006.01) A61K 31/5377 (2006.01) A61P 1/00 (2006.01) C07C 233/25 (2006.01) C07C 233/75 (2006.01) C07D 207/08 (2006.01) C07D 207/26 (2006.01) C07D 207/27 (2006.01) C07D 209/48 (2006.01) C07D 209/54 (2006.01) C07D 209/66 (2006.01) C07D 211/40 (2006.01) C07D 213/16 (2006.01) C07D 213/40 (2006.01) C07D 213/89 (2006.01) C07D 217/06 (2006.01) C07D 295/08 (2006.01) C07D 295/092 (2006.01) C07D 295/12 (2006.01) C07D 295/13 (2006.01) C07D 2
Patent
CA 2408288
The present invention relates to novel substituted diamine derivatives for the formula (I) wherein R1, R2, R3, R4, X1, X2, X3, X4, A , Y and n are as described in the specification, pharmaceutical compositions containing them and intermediates used in their manufacture. More particularly, the compounds of the invention are motilin receptor antagonists useful for the treatment of associated conditions and disorders such as gastrointestinal reflux disorders, eating disorders leading to obesity and irritable bowel syndrome.
La présente invention porte sur de nouveaux dérivés de diamine substitués de la formule (I) dans laquelle R?1, R?2¿, R?3¿, R?4¿, X?1¿, X?2¿, X?3¿, X?4¿, A, Y et n sont tels que décrits dans la demande, sur des compositions pharmaceutiques les contenant et sur des intermédiaires utilisés dans leur fabrication. Les composés de cette invention sont notamment des antagonistes des récepteurs de la motiline utiles dans le traitement d'états pathologiques et troubles associés tels que le reflux gastro-oesophagien, les troubles de l'alimentation à l'origine de l'obésité et du syndrome du côlon irritable.
Johnson Sigmond G.
Rivero Ralph A.
Ogilvy Renault Llp/s.e.n.c.r.l.,s.r.l.
Ortho-Mcneil Pharmaceutical Inc.
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