G - Physics – 01 – N
Patent
G - Physics
01
N
G01N 33/68 (2006.01) C12Q 1/48 (2006.01)
Patent
CA 2375450
The present invention is directed to methods to identify test compounds that alter circadian rhythms of mammals, and more specifically, directed to methods for determining the ability of a test compound to alter hCKI .delta. and .epsilon. phosphorylation of a human Period protein. The present invention is also directed to a method for determining the ability of a test compound to selectively alter phosphorylation, interaction with, or alternatively degradation, of one or more human Period proteins relative to its ability to alter phosphorylation, interaction with, or alternatively degradation, of a different human Period protein.
La présente invention concerne des méthodes d'identification de composés tests qui modifient les rythmes circadiens des mammifères, et plus particulièrement des méthodes de détermination de la capacité d'un composé test à modifier la phosphorylation hCKI delta et epsilon d'une protéine de période humaine. Cette invention concerne aussi une méthode de détermination de la capacité d'un composé test à modifier de manière sélective la phosphorylation, l'interaction ou la dégradation d'au moins une protéine de période humaine par rapport à sa capacité à modifier la phosphorylation, l'interaction ou la dégradation d'une différente protéine de période humaine.
Camacho Fernando
Keesler George
Mondadori Cesare
Yao Zhengbin
Aventis Pharmaceuticals Inc.
Aventisub II Inc.
Bereskin & Parr Llp/s.e.n.c.r.l.,s.r.l.
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