C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/12 (2006.01) A61K 38/17 (2006.01) C07K 14/47 (2006.01) C12Q 1/68 (2006.01) A61K 38/00 (2006.01)
Patent
CA 2312007
The invention relates to activation of apoptosis by means of interference of the function of Bip-like compounds. Also the invention relates to anti-tumor therapies with compounds, which negatively interfere with Bip-like compounds leading to induction of apoptosis, resulting in the elimination of tumor cells. Also the invention relates to therapies for diseases related to aberrant apoptosis induction, such as auto-immune diseases. Also the invention describes the diagnosis of cells, which are susceptible to apoptin or apoptin- like induces apoptosis.
L'invention porte sur l'activation de l'apoptose par interférence de la fonction des composés de type B¿ip?. L'invention porte également sur des thérapies antitumorales utilisant des composés qui interfèrent négativement avec des composés de type B¿ip? conduisant à l'induction de l'apoptose et entraînant l'élimination des cellules tumorales. L'invention porte encore sur des thérapies s'appliquant aux maladies apparentées à l'induction de l'apoptose aberrante telles que des maladies autoimmunes. L'invention porte enfin sur le diagnostic des cellules sensibles à l'apoptose induite par l'apoptine ou une protéine analogue à l'apoptine.
Danen-Van Oorschot Astrid Adriana Anna Maria
Noteborn Mathieu Hubertus Maria
Borden Ladner Gervais Llp
Leadd B.v.
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