A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 35/12 (2006.01) A61K 48/00 (2006.01) C07K 1/14 (2006.01) C12N 15/00 (2006.01)
Patent
CA 2691199
Methods and compositions are provided that are utilized for treatment and/or prevention of intraventricular hemorrhage or progressive hemorrhagic necrosis (PHN), particularly following spinal cord injury. In particular, the methods and compositions are inhibitors of a particular NCca-ATP channel and include, for example, inhibitors of SUR1 and/or inhibitors of TRPM4. Kits for treatment and/or prevention of of intraventricular hemorrhage or progressive hemorrhagic necrosis (PHN), particularly following spinal cord injury, are also provided. The present invention also concerns treatment and/or prevention of intraventricular hemorrhage in infants, including premature infants utilizing one or more inhibitors of the channel is provided to the infant, for example to brain cells of the infant. Methods and compositions are provided that are utilized for treatment and/or prevention of intraventricular hemorrhage or progressive hemorrhagic necrosis (PHN), particularly following spinal cord injury. In particular, the methods and compositions are inhibitors of a particular NCca-ATP channel and include, for example, inhibitors of SUR1 and/or inhibitors of TRPM4. Kits for treatment and/or prevention of of intraventricular hemorrhage or progressive hemorrhagic necrosis (PHN), particularly following spinal cord injury, are also provided. The present invention also concerns treatment and/or prevention of intraventricular hemorrhage in infants, including premature infants utilizing one or more inhibitors of the channel is provided to the infant, for example to brain cells of the infant.
L'invention concerne des procédés et des compositions qui sont utilisés pour le traitement et/ou la prévention de l'hémorragie intraventriculaire ou de la nécrose hémorragique progressive (PHN), en particulier suite à une lésion de la moelle épinière. En particulier, les procédés et les compositions sont des inhibiteurs d'un canal NCca-ATP particulier et comprennent par exemple des inhibiteurs de SUR1 et/ou des inhibiteurs TRPM4. L'invention concerne également des trousses pour le traitement et/ou la prévention de l'hémorragie intraventriculaire ou de la nécrose hémorragique progressive (PHN), en particulier suite à une lésion de la moelle épinière. La présente invention concerne en outre le traitement et/ou la prévention de l'hémorragie intraventriculaire chez les enfants en bas âge, y compris les prématurés, à l'aide d'un ou de plusieurs inhibiteurs du canal administrés à l'enfant en bas âge, par exemple aux cellules du cerveau de l'enfant en bas âge.
Bereskin & Parr Llp/s.e.n.c.r.l.,s.r.l.
University Of Maryland Baltimore
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