Method of using and compositions comprising immunomodulatory...

Details Method of using and compositions comprising immunomodulatory... Method of using and compositions comprising immunomodulatory...

A - Human Necessities

61

K

A61K 31/455 (2006.01)

Patent

CA 2565447

Methods of treating, preventing and/or managing a myeloproliferative disease are disclosed. Specific methods encompass the administration of an immunomodulatory compound, or a pharmaceutically acceptable salt, solvate, hydrate, stereoisomer, clathrate, or prodrug thereof, alone or in combination with a second active agent, and/or the transplantation of blood or cells. Particular second active agents are capable of suppressing the overproduction of hematopoietic stem cells or ameliorating one or more of the symptoms of a myeloproliferative disease. Pharmaceutical compositions, single unit dosage forms, and kits suitable for use in methods of the invention are also disclosed.

Des procédés de traitement, de prévention et/ou de gestion d'une maladie myéloproliférative sont décrits. Des procédés spécifiques englobent l'administration d'un composé immunomodulateur ou d'un sel, d'un solvate, d'un hydrate, d'un stéréo-isomère, d'un clathrate ou d'un précurseur de ceux-ci, acceptables en termes pharmaceutiques, seul ou en combinaison avec un second agent actif, et/ou la transplantation de sang ou de cellules. Des seconds agents actifs particuliers peuvent supprimer la surproduction de cellules souches hématopoïétiques ou améliorer un ou plusieurs des symptômes d'une maladie myéloproliférative. Des compositions pharmaceutiques, des formes de dosage à élément unique et des trousses appropriées à une utilisation dans des procédés de l'invention sont également décrites.

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