C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 265/34 (2006.01) A61K 31/47 (2006.01) A61K 31/495 (2006.01) A61K 31/535 (2006.01) A61K 31/54 (2006.01) C07D 221/10 (2006.01) C07D 241/38 (2006.01) C07D 279/14 (2006.01) C07D 403/06 (2006.01) C07D 409/06 (2006.01) C07D 413/06 (2006.01) C07D 417/06 (2006.01)
Patent
CA 2083146
2083146 9119719 PCTABS00008 The present invention comprises the compounds selected from the group of compounds represented by formula (1), wherein R1 and R2 are selected from the group consisting of H and OA, wherein A is H or is selected from the group consisting of hydrocarbyl radicals having from 1 to about 12 carbon atoms, or A is -COR5, -CONHR5, or -COOR5, wherein R5 is selected from the group consisting of hydrocarbyl radicals having between 1 and about 12 carbon atoms and wherein R1, R2 and R5 are optionally substituted with one or more halogen atoms; X is selected from the group consisting of CH2, oxygen, sulfur, NH or NR3, wherein R3 is a lower alkyl radical having from 1 to about 4 carbon atoms; R4 is selected from the group consisting of H, R3, COOR6, and -(CH2)n2-CH(R7)-Ar, wherein R6 is H or R3, n is 0 or an integer of from 1 to about 4, R7 is selected from the group consisting of R3, OR3, OCOR3 and H, and Ar is selected from the group consisting of radicals represented by general formulae: (a), (b), (c), (d), (e), (f), (g), wherein Y is selected from the group consisting of hydroxy, nitro, cyano, azido, amino, acylamino, carboxyamido, trifluoromethyl, sulfate, sulfonamido, halogen, hydrocarbyl and heteroatom-substituted hydrocarbyl radicals, wherein said heteroatoms are selected from the group consisting of halogen, nitrogen, oxygen, sulfur, and phosphorous and said hydrocarbyl radicals comprise from 1 to about 12 carbon atoms, a is 0 or an integer of from 1 to 2, W is oxygen, sulfur or nitrogen and Z represents two hydrogen radicals, oxygen or sulfur; with the proviso that when Z represents 2 hydrogen radicals, then R4 cannot be H, and pharmaceutical compositions comprising said compounds and a pharmaceutically-acceptable vehicle. Said compounds and compositions are effective for inducing a dopaminergic response in a subject, e.g., a mammal, and are useful for alleviating glaucoma, parkinsonism, etc., and inducing weight loss.
Minaskanian Gevork
Peck James V.
Macrae & Co.
Whitby Research Inc.
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