C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
530/13, 150/9, 1
C12N 15/12 (2006.01) C07K 14/705 (2006.01) C12N 1/21 (2006.01) C12N 5/10 (2006.01) G01N 33/566 (2006.01)
Patent
CA 2003459
Abstract of the Disclosure Disclosed is the basis for novel assays for detecting and pharmacologically characterizing agents that affect human muscle nicotinic acetylcholine receptor function. Also disclosed are recombinant means for producing human muscle nicotinic acetylcholine receptor and the various subunits thereof, and fragments of these subunits. Featured is the novel aspect of discovering the existence of muscle-type receptors in a human neuronal line and the consequent use of such receptors to assay the effects of agents that might affect acetylcholine receptors in human skeletal muscles.
Lindstrom Jon M.
Schoepfer Ralf D.
Lindstrom Jon M.
Macrae & Co.
Schoepfer Ralf D.
The Salk Institute For Biological Studies
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