Antineoplastic modified imidazoacridines

Details Antineoplastic modified imidazoacridines Antineoplastic modified imidazoacridines

C - Chemistry, Metallurgy

07

D

C07D 471/06 (2006.01) A61K 31/47 (2006.01) C07D 219/06 (2006.01)

Patent

CA 2051356

An antineoplastic compound of formula I, of particular interest for the treatment of leukaemia and optionally in the form of an acid addition salt: (see formula I) in which: R represents: -OH or -OR' (wherein R' represent alkyl, e.g. C1-C6 alkyl such as methyl>. R1a, and R1b, which may be identical or different, represent hydrogen or alkyl (e.g. C1-C3 alkyl such as methyl) which is optionally substituted e.g. by a hydroxyl, an amino, a N-alkyl- amino or a N,N'-dialkylamino group as, for example in the substituents: hydroxyethyl, aminoethyl, N-alkylaminoethyl and N,N'-dialkylaminoethyl, such N alkyl groups preferably containing 1-4 carbon atoms. n is 2-5 and R2 represents hydrogen, or alkyl.

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