Evaluating and predicting clinical outcomes by gene...

Details Evaluating and predicting clinical outcomes by gene... Evaluating and predicting clinical outcomes by gene...

C - Chemistry, Metallurgy

12

Q

C12Q 1/68 (2006.01)

Patent

CA 2393136

Methods of determining clinical outcomes in patients sufering from a pathological condition or syndrome are provided. Levels of intracellular gene expression are measured from a clinical sample provided by the patient, and the levels are compared to reference levels. Deviations from reference levels are predictive of clinical outcomes, for example, disease progression or response to therapeutic intervention.

L'invention concerne des méthodes permettant de déterminer des résultats cliniques chez des patients souffrant d'un état ou d'un syndrome pathologique. On mesure des niveaux d'expression génique intracellulaire à partir d'un échantillon clinique prélevé chez le patient, et on compare ces niveaux à des niveaux de référence. Les déviations par rapport à ces niveaux de référence sont prédictives de résultats cliniques, par exemple, de la progression d'une maladie ou d'une réponse à une intervention thérapeutique.

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