A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
167/215
A61K 31/535 (2006.01) A61K 31/47 (2006.01)
Patent
CA 2029421
ABSTRACT Presented are pharmaceutical compositions comprising in admixture with a carrier a compound of; (a) the formula (I) or a pharmaceutically acceptable salt thereof: Image (I) wherein Rl and R2 are each hydrogen, methyl, trifluoromethyl, carboxy, methoxycarbonyl or ethoxycarbonyl, and R3 is hydrogen or hydroxy; (b) the formula (II) or a pharmaceutically acceptable salt thereof: Image (II) wherein Rl, R2 and R3 are as defined; (c) the formula (III) or a pharmaceutically acceptable salt thereof: Image (III) wherein R4 and R5 are each hydrogen or form, by incorporation of C1 and C2 carbon atoms, a condensed [2.1-b] pyridine ring optionally substituted with a hydroxyl group or a carboxyl group, and R6 is hydrogen or hydroxy; or (d) the formula (IV) or a pharmaceutically acceptable salt thereof: Image (IV) wherein R4, R5 and R6 are as defined. The compositions are used to inhibit Maillard's reaction in human body, the reaction which may be responsible for the development of diabetic complications and age-associated disorders. Methods of treatment and prophylaxis of such complications and disorders are also presented.
G. Ronald Bell & Associates
Senju Pharmaceutical Co. Ltd.
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