Substrate trapping protein tyrosine phosphatases

Details Substrate trapping protein tyrosine phosphatases Substrate trapping protein tyrosine phosphatases

C - Chemistry, Metallurgy

12

N

C12N 9/16 (2006.01) A61K 38/46 (2006.01) C12Q 1/42 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2262440

Novel protein tyrosine phosphatases in which the invariant aspartate residue is replaced with an alanine residue and which bind to a tyrosine phosphorylated substrate and are catalytically attenuated are described. Also described are methods of identifying tyrosine phosphorylated proteins which complex with the described protein tyrosine phosphatases.

Cette invention concerne de nouvelles protéine-tyrosine-phosphatases dans lesquelles le reste d'aspartate invariant est remplacé par un résidu d'alanine, qui se lient à un substrat phosphorylé sur tyrosine et possèdent une activité catalytique atténuée. L'invention se rapporte également à des procédés d'identification de protéines phosphorylées sur tyrosine qui forment des complexes avec les protéine-tyrosine-phosphatases décrites ci-dessus.

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