Trifunctional compounds having specificity for multi-drug...

Details Trifunctional compounds having specificity for multi-drug... Trifunctional compounds having specificity for multi-drug...

C - Chemistry, Metallurgy

07

K

C07K 16/30 (2006.01) A61K 39/395 (2006.01) A61K 47/48 (2006.01) A61K 49/00 (2006.01) A61K 49/08 (2006.01) A61K 51/10 (2006.01) C07K 16/46 (2006.01) G01N 33/563 (2006.01) G01N 33/574 (2006.01) G01N 33/577 (2006.01) A61K 38/00 (2006.01) A61K 43/00 (1990.01)

Patent

CA 2113578

2113578 9302105 PCTABS00019 The present invention relates to trifunctional compounds having specific reactivity with P-glycoproteins associated with multi-drug resistant (MDR) tumor cells. The compounds can optionally be specific for diagnostic and/or therapeutic agents as well and are thus contained in pharmaceutical compositions. Methods for detecting and treating patients with tumors expressing P-glycoproteins associated with MDR cells are also provided.

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