C - Chemistry – Metallurgy – 12 – Q
Patent
C - Chemistry, Metallurgy
12
Q
C12Q 1/68 (2006.01) A61K 31/7088 (2006.01) A61K 39/395 (2006.01) A61P 35/00 (2006.01) C07H 21/04 (2006.01) C07K 14/715 (2006.01) C07K 16/00 (2006.01) C07K 16/24 (2006.01) C07K 16/28 (2006.01) C12N 15/11 (2006.01) C12N 15/85 (2006.01) G01N 33/53 (2006.01)
Patent
CA 2323525
The present invention relates to the identification of a novel role of CXCR-4 in cell transformation and aberrant cellular proliferation. In particular, the present invention relates to the altered gene expression of CXCR-4 in a number of primary tumors and cell lines derived from tumors, in addition to, the altered gene expression of ligands for CXCR- 4. Further, the present invention relates, in part, to the Applicants' surprising discovery that the inhibition of CXCR-4 gene expression or the inhibition of CXCR-4 activity in transformed cells reverses the transformed phenotype.
La présente invention concerne l'identification d'un nouveau rôle du CXCR-4 dans la transformation cellulaire et dans une prolifération cellulaire anormale. En particulier, la présente invention concerne l'expression génique modifiée du CXCR-4 dans un certain nombre de tumeurs primitives et de lignées cellulaires dérivées de ces tumeurs, en plus de l'expression génique modifiée de ligands du CXCR-4. En outre, les déposants ont découvert avec surprise que l'inhibition de l'expression du gène CXCR-4 ou l'inhibition de l'activité de CXCR-4 dans des cellules transformées inverse le phénotype transformé.
Boynton Alton L.
Murphy Gerald P.
Sehgal Anil
Fetherstonhaugh & Co.
Northwest Biotherapeutics Inc.
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