Novel dna-cleaving antitumor agents

Details Novel dna-cleaving antitumor agents Novel dna-cleaving antitumor agents

C - Chemistry, Metallurgy

07

D

C07D 235/08 (2006.01) A61K 31/137 (2006.01) A61K 31/4184 (2006.01) A61P 31/04 (2006.01) A61P 31/12 (2006.01) A61P 35/00 (2006.01) C07C 251/16 (2006.01)

Patent

CA 2337517

A chemical composition and method of use of the composition is described. The chemical composition includes an aza-enediynes, aza-enyne allenes, or an aza- diallenes. These compounds are preferably non-hydrolyzable, cationic compounds that bind to nucleic acids. In addition it is believed that these compounds may undergo chemical reactions in the presence of a nucleic acid to generate reactive intermediates that cleave nucleic acids.

L'invention concerne une composition chimique et son procédé d'utilisation. Cette composition chimique comprend des aza-ènediynes, des allènes d'aza-enyne ou des aza-diallènes. Ces composés sont, de préférence, des composés cationiques non hydrolysables se fixant aux acides nucléiques. On pense, de plus, que ces composés peuvent subir des réactions chimiques en présence d'un acide nucléique afin de générer des intermédiaires réactifs clivant les acides nucléiques.

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