Peptide analogs as selective inhibitors of thrombin...

Details Peptide analogs as selective inhibitors of thrombin... Peptide analogs as selective inhibitors of thrombin...

C - Chemistry, Metallurgy

07

K

C07K 7/06 (2006.01) C07K 7/08 (2006.01) C07K 14/745 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2382056

The invention relates to inhibiting human platelet aggregation, thrombosis and cell activation mediated by PAR1 with peptide analogs corresponding to those of Formula I and II, wherein Formula I is: Arg-Gly-Lys-Z4-Cys (SEQ ID NO: 43) wherein: Z4 is any naturally occurring amino acid, excluding cysteine; and wherein Formula II is: Arg-Gly-Asp-Z4-Cys (SEQ ID NO: 44) wherein: Z4 is any naturally occurring amino acid, excluding cysteine.

L'invention concerne l'inhibition de l'agrégation plaquettaire humaine, de la thrombose et de l'activation cellulaire induite par PAR1, au moyen d'analogues peptidiques représentés par les formules I et II. Formule I: Arg-Gly-Lys-Z¿4?-Cys (SEQ ID NO: 43), Z¿4? représentant n'importe quel acide aminé naturel à l'exception de la cystéine. Formule II: Arg-Gly-Asp-Z¿4?-Cys (SEQ ID NO: 44), Z¿4? représentant n'importe quel acide aminé naturel à l'exception de la cystéine.

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