C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/16 (2006.01) A01K 67/027 (2006.01) A61K 38/08 (2006.01) A61K 38/10 (2006.01) A61K 38/22 (2006.01) A61P 1/00 (2006.01) A61P 1/06 (2006.01) A61P 3/04 (2006.01) A61P 3/10 (2006.01) A61P 9/12 (2006.01) C07K 14/575 (2006.01) C07K 16/26 (2006.01) C12N 5/10 (2006.01) C12N 15/63 (2006.01) C12Q 1/00 (2006.01)
Patent
CA 2560011
The invention relates to nucleic acids and polypeptides referred to herein as cospeptin and cosmedin. Cospeptin, cosmedin, analogs and mimetics thereof act in signaling pathways, and are shown to modulate hypertension and other cardiovascular parameters, and gastric emptying. Cospeptin and cosmedin nucleic acid compositions find use in identifying homologous or related proteins and the DNA sequences encoding such proteins; in producing the polypeptide; and in studying associated physiological pathways.
La présente invention a trait à des acides nucléiques et des polypeptides désignés cospeptine et cosmédine. La cospeptine, la cosmédine, leurs analogues et mimétiques agissent dans des voies de signalisation, et présentent une activité modulatrice de l'hypertension et d'autres paramètres cardio-vasculaires, et la vidange gastrique. Les compositions à base d'acides nucléiques de la cospeptine et de la cosmédine sont utiles dans l'identification de protéines homologues et associées et des séquences d'ADN codant pour de telles protéines ; dans la production du polypeptide ; et dans l'étude de voies physiologiques associées.
Avsian-Kretchmer Orna
Barrett Terrance D.
Hsu Sheau Yu Teddy
Hsueh Aaron J.w.
Morton Magda F.
Fetherstonhaugh & Co.
Janssen Pharmaceutica N.v.
The Board Of Trustees Of The Leland Stanford Junior University
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