Amidinophenol derivatives

Details Amidinophenol derivatives Amidinophenol derivatives

C - Chemistry, Metallurgy

07

C

C07C 257/18 (2006.01) A61K 31/24 (2006.01) A61K 31/33 (2006.01) A61K 31/66 (2006.01) C07C 257/14 (2006.01) C07C 257/16 (2006.01) C07D 207/337 (2006.01) C07D 209/42 (2006.01) C07D 211/14 (2006.01) C07D 211/26 (2006.01) C07D 211/34 (2006.01) C07D 213/58 (2006.01) C07D 233/54 (2006.01) C07D 233/61 (2006.01) C07D 239/26 (2006.01) C07D 307/14 (2006.01) C07D 307/16 (2006.01) C07F 9/32 (2006.01) C07F 9/40 (2006.01)

Patent

CA 2158676

The compounds of the formula (IB) and processes for the preparation thereof, leukotrieneB4 antagonist containing the compounds of the formula (IA) or the formula(IB) as active ingredient, and phospholipaseA2 and/or trypsin antagonist containing the compounds of the formula (IB) as active ingredient (wherein R1 and R2 are -COOR4 etc; A is alkylene etc; R3 is -CON (R7)R8 etc; D ring is the formula (i), (ii) etc; T is NH or oxygen; E is bond, -C (R300)=C (R400)-; A0 is bond, alkylene, oxyalkylene, thioalkylene, (substituted)alkenylene; R is -CON (R50)R60 -N (R50)R60 etc). Image (IA) [Effect] The compounds of the present invention is useful for prevention or treatment of inflammation, allergy, rheumatoid arthritis, inflammatory bowel diseases, psoriasis, nonsteroidal anti-inflammatory agent-induced stomach diseases, adult respiratory distress syndrome, cardiac infarction, hemodialysis-induced neutropenia etc, prevention and treatment of inflammatory diseases, allergic diseases, disseminated intravascular coagulation pancreatitis or severity in pancreatitis or multiple organ failure.

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