Pharmaceutical compositions comprising polyanionic polymers...

A - Human Necessities – 61 – K

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Details

A61K 48/00 (2006.01) A61K 47/32 (2006.01) A61K 47/34 (2006.01) A61K 47/48 (2006.01)

Patent

CA 2472170

The present invention is directed to polynucleotide compositions containing (a) a polynucleotide or derivative thereof and (b) a block copolymer having a polyether segment and a polyanion segment, compositions containing (a) a polynucleotide or its derivative thereof, (b) at least one polyanionic polymer, and (c) at least one amphiphilic block copolymer, and methods of using these compositions for gene therapy.

La présente invention se rapporte à des compositions polynucléotidiques contenant (a) un polynucléotide ou un dérivé de polynucléotide et (b) un copolymère séquencé ayant un segment polyéther et un segment polyanion, à des compositions contenant (a) un polynucléotide ou un dérivé de polynucléotide, (b) au moins un polymère polyanionique, et (c) au moins un copolymère séquencé amphiphile, ainsi qu'à des procédés d'utilisation de ces compositions en thérapie génique.

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