Slow-release matrix pellets and the production thereof

Details Slow-release matrix pellets and the production thereof Slow-release matrix pellets and the production thereof

A - Human Necessities

61

K

A61K 9/22 (2006.01) A61K 9/16 (2006.01)

Patent

CA 2188185

Disclosed are sustained-release matrix pellets of spherical to lenticular shape and uniform maximum diameter in the range of 0-5 to 4 mm, consisting of a) 0.1 to 87 wt % of at least one biologically active compound, b) 5 to 50 wt % of at least one water-insoluble polymer, c) 5-45 wt % of at least one lipophilic component as plasticizer for the b) polymer, d) 3 to 40 wt % of a natural or semisynthetic gelling agent, e) 0 to 50 wt% of one or more common formulation auxiliaries.

L'invention concerne des pellets à libération retard à matrice d'enrobage, sphériques ou lentiformes, dont le diamètre maximal uniforme se situe entre 0,5 et 4 mm. Ces pellets contiennent: a) entre 0,1 et 87 % en poids d'au moins un composé à activité biologique, b) entre 5 et 50 % en poids d'au moins un polymère insoluble dans l'eau, c) entre 5 et 45 % en poids d'au moins un constituant lipophile servant de plastifiant au polymère b), d) entre 3 et 40 % en poids d'un gélifiant naturel ou semi-synthétique, e) entre 0 et 50 % en poids d'un ou de plusieurs auxiliaire(s) de formulation.

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