C - Chemistry – Metallurgy – 07 – C
Patent
C - Chemistry, Metallurgy
07
C
C07C 253/30 (2006.01) C07C 255/33 (2006.01) C07C 255/35 (2006.01) C07C 255/37 (2006.01) C07C 255/45 (2006.01) C07C 255/51 (2006.01) C07D 213/57 (2006.01) C07D 231/56 (2006.01) C07F 7/10 (2006.01) C07C 255/32 (2006.01)
Patent
CA 2306004
A process is described for preparing an aromatic compound substituted by a tertiary nitrile of Formula (1Ø0): (see formula 1Ø0) comprising treating a substituted aromatic compound of Formula (2Ø0): (see formula 2Ø0) with a secondary nitrile of Formula (3Ø0): (see formula 3Ø0) in the presence of a base having a pK a numerical value in the range of from about 17 to about 30, provided that the difference in pK a numerical values between said base and the corresponding tertiary nitrile of Formula (3Ø0) is no more than about 6; in an aprotic solvent having a dielectric constant (.epsilon.) of less than about 20; and at a reaction temperature in the range of from about 0 °C to about 120 °C; whereby there is formed said tertiary-nitrile- substituted aromatic compound final product of Formula (1Ø0); wherein the constituent parts W1, W2, W3, W4, and W5; and the substituent moieties R1, R2, R3, R4, R5, R6, and R7 in the compounds of Formulas (1Ø0), (2Ø0) and (3Ø0) are selected from known organic groups and radicals as further detailed in the instant specification.
Pfizer Products Inc.
Smart & Biggar
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