Mercapto-acylamino acids

Details Mercapto-acylamino acids Mercapto-acylamino acids

C - Chemistry, Metallurgy

07

C

C07C 323/59 (2006.01) A61K 31/00 (2006.01) A61K 38/22 (2006.01) A61K 38/55 (2006.01) C07C 323/60 (2006.01) C07C 327/32 (2006.01) C07C 327/34 (2006.01) C07D 333/24 (2006.01)

Patent

CA 2051652

2051652 9012003 PCTABS00002 Novel mercapto-acylamino acids of the formula (I), wherein Q is hydrogen or R7CO-; R1 is lower alkyl, cyclolower alkyl, aryl or heteroaryl; R2 is hydrogen; lower alkyl; cyclolower alkyl; lower alkyl substituted with hydroxy, lower alkoxy, mercapto, lower alkylthio, aryl or heteroaryl; aryl; or heteroaryl; R3 is -OR5 or -NR5R6; R4 and R9 are independently -(CH2)qR8, provided that when R4 and R9 are both hydrogen, R2 is biphenylyl, phenoxyphenyl, phenylthiophenyl, naphthyl, heteroaryl, or lower alkyl substituted with hydroxy, lower alkoxy, mercapto or lower alkylthio; R5 and R6 are independently selected from the group consisting of hydrogen, lower alkyl, hydroxy lower alkyl, lower alkoxy, lower alkyl and aryl lower alkyl, or R5 and R6 together with the nitrogen to which they are attached form a 5-7 membered ring; R7 is hydrogen, lower alkyl or aryl; R8 is hydrogen, hydroxy, lower alkoxy, mercapto, lower alkylthio, aryl or heteroaryl; n is 1 or 2; p is 0 or 1; q is 0,1 or 2; and t is 0 or 1; and the pharmaceutically acceptable salts thereof useful in the treatment of cardiovascular disorders and pain conditions and combinations of mercapto-acylamino acids and atrial natriuretic factors or angiotensin converting enzyme inhibitors useful for treating cardiovascular disorders are disclosed.

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