A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 9/20 (2006.01) A61K 31/365 (2006.01)
Patent
CA 2717456
Modified release pharmaceutical compositions comprising mycophenolate as the active agent or its pharmaceutically acceptable salts, esters, polymorphs, isomers, prodrugs, solvates, hydrates, or derivatives thereof, wherein the said composition exhibits a biphasic release profile when subjected to in- vitro dissolution and/or upon administration in- vivo are provided. The composition provides a drug release in a manner such that the drug levels are maintained above the therapeutically effective concentration (EC) constantly for an extended duration of time. Further, the difference between the maximum plasma concentration of the drug (Cmax) and the minimum plasma concentration of the drug (Cmjn), and in turn the flux defined as ((Cmax-Cmjn)/Cavg) is minimal. The present invention also provides process of preparing such dosage form compositions and prophylactic and/or therapeutic methods of using such compositions.
La présente invention concerne des compositions pharmaceutiques à libération modifiée comprenant du mycophénolate en tant quagent actif ou ses sels, esters, polymorphes, isomères, promédicaments, solvates, hydrates ou dérivés pharmaceutiquement acceptables de celui-ci, où ladite composition présente un profil de libération biphasique lorsquelle est soumise à une dissolution in vitro et/ou après administration in vivo. La composition produit une libération de médicament de telle manière que les taux de médicament soient constamment maintenus au-dessus de la concentration thérapeutique efficace (CE) pendant une durée prolongée. De plus, la différence entre la concentration plasmatique maximale du médicament (Cmax) et la concentration plasmatique minimale du médicament (Cmin) et par conséquent le flux défini comme étant ((Cmax - Cmin)/Cmoy) est minimal. La présente invention propose en outre un procédé de préparation de telles compositions de forme pharmaceutique et des procédés prophylactiques et/ou thérapeutiques dutilisation de telles compositions.
Jain Rajesh
Singh Sukhjeet
Panacea Biotec Limited
Sim & Mcburney
LandOfFree
Modified release pharmaceutical compositions comprising... does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Modified release pharmaceutical compositions comprising..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Modified release pharmaceutical compositions comprising... will most certainly appreciate the feedback.
Profile ID: LFCA-PAI-O-1419044